Supplemental Figures 1-6 and Supplemental Tables 1-3 from NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure 1. Elevated NQO1 expression in patients with HNC correlates with poor overall survival to standard therapy; Supplemental Figure 2. Functional shRNA-NQO1 knockdown rescues β-lapinduced cell death; Supplemental Figure 3. β-Lap-induced NQO1 dependent DNA damage and NAD+ depletion; Supplemental Figure 4. Combination sublethal doses of β-lap and low dose IR induce NQO1 dependent anti-cancer lethality; Supplemental Figure 5. Cooperative antitumor efficacy using a combination of IR and β-lap to treat HNC xenograft models; Figure 6. Expression of Ki-67 after combination of β-lap and IR in HNC xenograft models; Supplemental Table 1. NQO1 enzyme activity and abrogation of activity in 41 HNC cell lines and primary human IMR90 fibroblasts; Supplemental Table 2. Equitoxic doses comparing single to combined treatment in HNC cells; Supplemental Table 3. Individual patient gender, age, subsite, stage, histology and IHC scoring for NQO1 and Catalase
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362484786