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Supplementary Figures 1-2 from Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure 1. MI-77301 induces upregulation of MDM2, p53, p21, PUMA, and cleavage of PARP in WHIM18 tumor tissues; Supplementary Figure 2. Treatment by MI-77301 alone, Fulvestrant alone or the combination does not affect the body weight of tumor-bearing mice.

DOI: 10.1158/1535-7163.22507789.v1

Authors: Jianfeng Lu, Donna McEachern, Shunqiang Li, Matthew J. Ellis, Shaomeng Wang

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362485032

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