Data from Genetic Variability of Smoking Persistence in African Americans
Year: 2023
Type: other
Abstract: To date, most genetic association analyses of smoking behaviors have been conducted in populations of European ancestry and many of these studies focused on the phenotype that measures smoking quantity, that is, cigarettes per day. Additional association studies in diverse populations with different linkage disequilibrium patterns and an alternate phenotype, such as total tobacco exposure which accounts for intermittent periods of smoking cessation within a larger smoking period as measured in large cardiovascular risk studies, can aid the search for variants relevant to smoking behavior. For these reasons, we undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study. A locus located approximately 4 kb downstream from the 3′-UTR of the brain-derived neurotrophic factor (BDNF) significantly influenced smoking persistence. In addition, independent variants rs12915366 and rs12914385 in the cluster of genes encoding nicotinic acetylcholine receptor subunits (CHRNA5–CHRNA3–CHRNB4) on 15q25.1 were also associated with the phenotype in this sample of African American subjects. To our knowledge, this is the first study to more extensively evaluate the genome in the African American population, as a limited number of previous studies of smoking behavior in this population included evaluations of only single genomic regions. Cancer Prev Res; 4(5); 729–34. ©2011 AACR.
Authors: Ajna Hamidovic, John L. Kasberger, Taylor R. Young, Robert J. Goodloe, Susan Redline, Sarah G. Buxbaum, Neal L. Benowitz, Andrew W. Bergen, Kenneth R. Butler, Nora Franceschini, Sina A. Gharib, Brian Hitsman, Daniel Levy, Yan Meng, George J. Papanicolaou, Sarah R. Preis, Bonnie Spring, Mindi A. Styn, Elisa K. Tong, Wendy B. White, Kerri L. Wiggins, Eric Jorgenson
Institutions: Northwestern University, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Broad Institute, Harvard University, Massachusetts Institute of Technology, Vanderbilt University, Vanderbilt University Medical Center, Jackson State University, SRI International, University of Mississippi Medical Center, University of North Carolina at Chapel Hill, University of Washington, National Heart, Lung, and Blood Institute, Framingham Heart Study, Boston University, University of Pittsburgh, University of California, Davis, Tougaloo College
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362485139