Supplemental Figures 1-7 and Supplemental Table 1 from Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer
Year: 2023
Type: supplementary-materials
Abstract: Figure S1 provides quality control from scRNA-seq analysis. Figure S2 indicates altered pathways in SULT2B1b KD cells. Figure S3 demonstrates TNF and SULT2B1b KD interact to further reduce AR activity in LNCaP cells. Figure S4 demonstrates that TNFR expression is not altered by SULT2B1b KD. Figure S5 demonstrates that SULT2B1b KD induces TRADD expression in LNCaP cells. Figure S6 indicates SULT2B1 is expressed at low levels. Figure S7 supports that TRAIL, TL1, and DAXX are not involved in apoptosis in SULT2B1b KD cells. Table S1 gives correlations of SULT2B1 with TNF-related genes.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362486571