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Supplementary figures and figure legends from Ku80-Targeted pH-Sensitive Peptide–PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation

Year: 2023

Type: supplementary-materials

Abstract: Fig. S1: pHLIP-αKu80(γ) binds to the mouse Ku80 sequence. Fig. S2: Validation of tumor vs. stromal cell sorting in EMT6-GFP cells. Fig. S3: Partial suppression of Ku80 expression induces radiosensitivity in cultured cancer cells. Fig. S4: pHLIP-αKu80(γ) causes tumor radiosensitization. Fig. S5: pHLIP-αKu80(γ) causes in vitro radiosensitization. Fig. S6: pHLIP-αKu80(γ) does not induce electrolyte abnormalities. Fig. S7: pHLIP-αKu80(γ) does not cause bone marrow suppression.

DOI: 10.1158/1541-7786.22517572.v1

Authors: Alanna R. Kaplan, Ha Pham, Yanfeng Liu, Stanley Oyaghire, Raman Bahal, Donald M. Engelman, Peter M. Glazer

Language: English

Topic: Radiation Therapy and Dosimetry

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362487190

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