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Supplementary Figures 1-6 from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 1.3MB, S1. Pearson correlation analysis of hESCs, HCCs and hPHS. S2. EHCC miRNAs are not capable of rescuing hepatic progenitor cell induction in Dgcr8 null mESCs during the in vitro differentiation process of mESCs along a hepatic lineage. S3. EHCC miRNAs cannot rescue the deficiency in hepatocyte differentiation in Dgcr8 null mESCs. S4. Experimental timeline of hPHs. S5. Global gene expression analysis between hPHs and hPHs expressing EHCC miRNAs. S6. Expression patterns of genes reported to be associated with HCCs, ESCs and hepatic progenitor stem cells following EHCC miRNA overexpression in hPHs

DOI: 10.1158/1541-7786.22517686.v1

Authors: Christine J. Jung, Sushma Iyengar, Kimberly R. Blahnik, Joy X. Jiang, Candice Tahimic, Natalie J. Torok, Ralph W. de vere White, Peggy J. Farnham, Mark Zern

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362487202

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