Supplementary Figure 4 from α-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 4.7MB, We further analyzed the tumors that formed from the injection of control and �-catulin-deficient USC-HN1 cell lines. We can observe and track injected cells by the tGFP reporter. A and B, checking for proliferation rate, we do not see a considerable difference between the two tumors, as assessed by the proliferative marker, Ki67. C and D, when analyzing the tumors for human-specific lymphatic vessel marker, lyve-1, the control tumor (C) had collective groups of cells that were able to invade the surrounding stroma and form their own lymphatic vessels, whereas �-catulin-deficient tumors (D) were unable to do so. E-F, IHC staining using phospho-JNK antibody show an increase in activated phospho-JNK in control tumor (E) compared to �-catulin-deficient tumor (F). Arrows indicate invasive tumor fronts in control tumors, whereas dashed lines indicate a less invasive tumor margin in �-catulin-deficient tumors
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362487260