Supplementary Figures 1-7 and Tables 1 and 2 from AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Fig. 1. AXL is a direct mediator of EMT Supplementary Fig. 2. AXL inhibition causes DNA damage and reduces levels of DNA repair markers. Supplementary Fig. 3. AXL knockdown cause DNA damage and decreases gene expression of DNA repair genes Supplementary Fig. 4. AXL inhibition is synergistic with PARP inhibition. Supplementary Fig. 5. AXL inhibition in combination with PARP inhibition causes increased subG1 and G2/M populations Supplementary Fig. 6. Correlation analysis with AXL expression in patient cohorts. Supplementary Fig. 7. AXL expression corresponds to expression of DNA repair proteins and EMT markers in patient cohorts Supplementary Table 1. Doubling time upon AXL knockdown Supplementary Table 2. DNA repair proteins and EMT markers analyzed by Reverse Phase Protein Assay
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362487511