Supplementary Figure 4 from Activity of Combined Androgen Receptor Antagonism and Cell Cycle Inhibition in Androgen Receptor Positive Triple Negative Breast Cancer
Year: 2023
Type: supplementary-materials
Abstract: Overlap between RNAseq datasets from MDA-MB-453 ARHigh cells and HCI-009 PDX mice treated with Sevi. scRNAseq was performed on untreated MDA-MB-453 cells cultured in full serum media. Cells were divided in groups based on their expression of AR, ARLow and ARHigh. RNAseq was performed on HCI-009 PDX tumor from mice treated daily with vehicle or 150mg/kg/day Sevi. (A) Venn diagram of overlap between gene signatures. (B) Biological pathways identified by examining the list of 208 genes that overlap between datasets. Numbers per pathway represent the number of genes associated with each pathway.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362488552