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Supplemental Figure 2 from Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Figure 2. HACE1 overexpression reduces activated Rac1 and attenuates ccRCC growth and survival. (A) Rac1 and HACE1 mRNA expression correlation from the KIRC TCGA Dataset (B) Rac1-GTP Pull-down assay of empty vector or HACE1 overexpressing 786-O cells. (C) Migration assay on empty vector or HACE1 overexpressing 786-O cells. (D) Cellular proliferation assay of empty vector or HACE1 overexpressing 786-O cells. (E) Soft agar assay results of empty vector or HACE1 overexpressing 786-O cells.

DOI: 10.1158/1535-7163.22520848

Authors: Erik T. Goka, Pallavi Chaturvedi, Dayrelis T. Mesa Lopez, Marc E. Lippman

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362490103

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