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Supplemental Figure 1 from Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Figure 1. Rac1 is a driver of ccRCC. (A) Rac1 mRNA expression in normal kidney and ccRCC patients from Jones Renal Cohort. (B) Rac1 DNA copy number analysis of normal blood, normal kidney, and kidney tumors from the KIRC TCGA dataset. (C) Rac isoform expression analysis in normal kidney and kidney tumors from the TCGA KIRC dataset. (D) PREX1, VAV1, TIAM1, and TRIO mRNA expression in normal kidney and kidney tumors from the TCGA KIRC dataset. (E) Rac1 mRNA expression by clinical stage from the TCGA KIRC dataset. (F) Boyden chamber cellular migration assay of 786-O transfected with siNSC or siRac1 oligonucleotides. (G) Cellular proliferation assay of 786-O transfected with siNSC or siRac1 oligonucleotides.

DOI: 10.1158/1535-7163.22520851

Authors: Erik T. Goka, Pallavi Chaturvedi, Dayrelis T. Mesa Lopez, Marc E. Lippman

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362490183

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