Work

Data from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases

Year: 2023

Type: other

Abstract: Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. (Mol Cancer Res 2008;6(5):760–9)

DOI: 10.1158/1541-7786.c.6542754.v1

Authors: Lei Xu, Steven S. Shen, Yujin Hoshida, Aravind Subramanian, Ken Ross, Jean-Philippe Brunet, Stephan N. Wagner, Sridhar Ramaswamy, Jill P. Mesirov, Richard O. Hynes

Institutions: Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Broad Institute, Austrian Academy of Sciences, Medical University of Vienna, Harvard University, Massachusetts General Hospital

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362490877

Cites: 22

Cited by:

Related to: 10