Supplementary Data, Supplemental Figures 1-7 from Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
Year: 2023
Type: supplementary-materials
Abstract: Figure S1. mTORC1 and mTORC2 are activated downstream of aberrant EGFR signaling in human GBM. Figure S2. mTOR complexes regulate expression of EZH2 and H3K27me3 in GBM cell lines and other types of cancer cell lines. Figure S3. EGFR activation translationally increases the level of EZH2. Figure S4. Aberrant EGFR signaling renders GBM cells sensitive to EZH2 inhibitors. Figure S5. mTORC1 regulates the expression of EZH2 translationally. Figure S6. mTORC2 regulates the production of S-adenosylmethionine (SAM). Figure S7. mTOR-dependent histone methylation epigenetically regulates tumor suppressor gene CDKN1A (p21) in GBM cells.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362492178