Work

Supplementary Figures 1 - 6 from Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 403K, Supplemental Figure 1. Heat map of 203 metabolites in 21 pairs of CAFs and NFs. Supplemental Figure 2. The distributions of "relative" t-scores for the 203 metabolites categorized into 46 biochemical subgroupings. Supplemental Figure 3. Total LAMP 2A expression in 8 NF/CAF pairs determined by quantitative Western blotting. Supplemental Figure 4: Alteration in glucose concentration has no consistent effect on NF or CAF growth. Supplemental Figure 5. pH calibration curve constructed for rhodamine-fluorescein (R/F)dextran labeled lysosomes in human fibroblasts. Supplemental Figure 6 (A,B,C,D) Rhodamine-fluorescein (R/F) ratios in arbitrary fluorescent units histograms of ROIs of 4 example CAF/NF pairs.

DOI: 10.1158/1541-7786.22516531.v1

Authors: Virendra K. Chaudhri, Gregory G. Salzler, Salihah A. Dick, Melanie S. Buckman, Raffaella Sordella, Edward D. Karoly, Robert Mohney, Brendon M. Stiles, Olivier Elemento, Nasser K. Altorki, Timothy E. McGraw

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362492589

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