Supplementary Tables 1 through 13 and Supplementary Table 15 from A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance
Year: 2023
Type: supplementary-materials
Abstract: PDF - 160K, Supplementary Table S1. Summary of the six next-generation sequencing (NGS) studies containing 241 paired melanoma tumor/normal samples. Supplementary Table S2. Summary of known driver mutations detected in the 241 melanoma samples. Table S3. Mutated genes significantly associated with BRAF-mutated samples (frequencygreater than or equal to 10% and p-value < 0.05) in the Hodis et al. study. Table S4. Mutated genes significantly associated with NRAS-mutated samples (frequencygreater than or equal to 10% and p-value < 0.05) in the Hodis et al. study. Table S5. Mutated genes significantly associated with BRAF-mutated samples (frequencygreater than or equal to 10% and p-value < 0.05) in the Krauthammer et al. study. Table S6. Mutated genes significantly associated with NRAS-mutated samples (frequencygreater than or equal to 10% and p-value < 0.05) in the Krauthammer et al. study. Table S7. Mutated genes significantly associated with BRAF-mutated samples identified by the meta-analysis but not significantly BRAF-associated in the Hodis et al. study (corresponds with Table 1). Table S8. Mutated genes significantly associated with NRAS-mutated samples identified by the meta-analysis but some of them not significantly NRAS-associated in the Hodis et al. study (corresponds with Table 2). Table S9. Mutated genes significantly associated with BRAF-mutated samples as identified by the meta-analysis but not significantly BRAF-associated in the Krauthammer et al. study (corresponds with Table 1). Table S10. Mutated genes significantly associated with NRAS-mutated samples as identified by the meta-analysis but most of them not significantly NRAS-associated in the Krauthammer et al. study. Supplementary Table S11. Meta-analysis defined mutated genes associated with BRAF-mutated samples (frequencygreater than or equal to 10%, p-value < 0.05 is shown in red) by histological subtype. Supplementary Table S12. Meta-analysis defined mutated genes associated with NRAS-mutated samples (frequencygreater than or equal to 10%, p-value < 0.05 is shown in red) by histological subtype. Supplementary Table S13. Meta-analysis identified guanine nucleotide-binding protein alpha-subunit (GNA) mutations in the 69 pan-negative melanoma samples. Table S15. Summary of Meta-analysis identified genes with mutations enriched in pan-negative sun-exposed melanoma samples (mutation frequency greater than or equal to 10% and p-value < 0.05).
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362494135