Supplementary tables S1-2, Supplementary figures S1-6, Captions for supplementary videos 1 to 7 from Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Table S1. Fluorescent antibody conjugation; Supplementary Table S2. Fiji macros for 3D image processing and analysis; Supplementary Figure S1. Comparison of 2D and 3D images of anti-PD-L1 antibody drug distribution in tumor at 12 h post injection; Supplementary Figure S2. 3D spatial pharmacokinetics of anti-PD-L1 antibody in tumor macrosections; Supplementary Figure S3. Fluorescence calibration curve for anti-PD-L1 antibody concentration in plasma; Supplementary Figure S4. Optimizing fixation and immunostaining conditions for 3D imaging macromolecular drug distribution in 400 μm thick tumor macrosections; Supplementary Figure S5. 3D mapping of different types of microvessels and their permeability with regards to anti-PD-L1 antibody drug penetration into tumor. Supplementary Figure S6. 3D visualization of macromolecular drug distribution in tumors.
Authors: Steve Seung-Young Lee, Vytautas P. Bindokas, Stephen J. Kron
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362494444