Supplemental Figures S1-S7; Supplemental Materials and Methods; and Supplemental Table S1 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
Year: 2023
Type: supplementary-materials
Abstract: Figure S1: Representative histological features of orthotropic DBT tumor 3 weeks after implantation Figure S2: Semi-quantitative analysis of microglial invasion of DBT tumors Figure S3: ST-11 reduces proliferation and triggers apoptosis in DBT cells in vitro Figure S4: ST-11 leaves interphase MT tips intact and mediates reversible effects on MT assembly Figure S5: ST-11 activates apoptosis in cultured T98G and DBT cells Figure S6: Paclitaxel reduces the viability of MDA-MB-231 cells Figure S7: Solubility and stability of ST-11 Movies: MT dynamics in T98G cells Supplemental materials & methods containing detailed experimental procedures Table S1: Response of T98G cells to 10 AI analogues as measured with WST-1
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362494465