Work

Supplementary Methods and Figures S1-S4 from Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Methods Supplementary References Figure S1. PIM and PI3K/AKT inhibitors synergize to suppress PCa cell growth and survival. Figure S2. PIM1 induces expression of ROS scavengers by NRF2 transcription activity. Figure S3. PIM1 promotes glucose carbon flux in various metabolic pathways. Figure S4. PIM and PI3K/AKT inhibitors downregulate NRF2 antioxidant response leading to oxidative DNA damages.

DOI: 10.1158/1535-7163.22504507.v1

Authors: Jin H. Song, Neha Singh, Libia A. Luevano, Sathish K.R. Padi, Koichi Okumura, Virginie Olive, Stephen M. Black, Noel A. Warfel, David W. Goodrich, Andrew S. Kraft

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362494484

Cites: 16

Cited by:

Related to: 10