Year: 2023
Type: article
Abstract: Aging is a topic of paramount importance in an increasingly elderly society and has been the focus of extensive research. Protein homeostasis (proteostasis) decline is a hallmark in aging and several age-related diseases, but which specific proteins and mechanisms are involved in proteostasis (de)regulation during the aging process remain largely unknown. Here, we used different text-mining tools complemented with protein-protein interaction data to address this complex topic. Analysis of the integrated protein interaction networks identified novel proteins and pathways associated to proteostasis mechanisms and aging or age-related disorders, indicating that this approach is useful to identify previously unknown links and for retrieving information of potential novel biomarkers or therapeutic targets.
Source: Biogerontology
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Awards: G1390952213, G1516346500, G1578237752, G1763632427, G3840324753, Unveiling the functions of NMRK1- and NMRK2-mediated NAD+ synthesis in neuronal and glial cells, G5224927334, Sem título, G5454278309, G6193589897, G7278841680, Instituto de Biomedicina - Aveiro, Centro de Investigação Interdisciplinar em Saúde
OpenAlex ID: W4362506401