Figure S11 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors
Year: 2023
Type: other
Abstract: Epigenome-wide association analysis identifying CpG sites that are significantly differentially methylated in breast milk relative to solid breast tissue. (A) adjusting only for age and parity, (B) adjusting for age, parity, and estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils (C) adjusting for age, parity, and family history of disease, and (D) adjusting for age, parity, family history of disease, and estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils. Red dashed lines indicate a significance threshold of FDR < 0.05. (E) Enrichment analysis for differentially methylated loci (FDR < 0.05) in breast milk relative to solid breast tissue after adjustment for age, parity, and cellular composition.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362514036