Work

Supplementary Figures S1-S3 from Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figures S1-S3: Supplementary Figure S1. AZD1480 abrogates STAT3 DNA binding while targeting JAK2 or STAT3 has little effect on viability or proliferation in cultured cells. Supplementary Figure S2. Pharmacodynamics of AZD1480 treatment. Supplementary Figure S3. Flow cytometry analysis of immune cell subpopulations in tumors and peritoneal washes from vehicle- and AZD1480-treated mice.

DOI: 10.1158/1535-7163.22501360

Authors: Galina Gritsina, Fang Xiao, Shane W. O'Brien, Rashid Gabbasov, Marisa A. Maglaty, Ren-Huan Xu, Roshan J. Thapa, Yan Zhou, Emmanuelle Nicolas, Samuel Litwin, Siddharth Balachandran, Luis J. Sigal, Dennis Huszar, Denise C. Connolly

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362526133

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