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Supplementary Figures S1-S3 from Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figures S1-S3. Supplementary Figure 1. BMH-9, BMH-22 and BMH-23 cause a reduction in RPA194 half life. Supplementary Figure 2. BMH-9, BMH-22 and BMH-23 do not activate the DNA damage response. Supplementary Figure 3. p53 activation by Nutlin-3 does not affect the integrity of the nucleolus or rRNA synthesis.

DOI: 10.1158/1535-7163.22501639

Authors: Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Zhewei Zhang, Taija af Hällström, Henna M. Moore, Paul Sirajuddin, Marikki Laiho

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362526337

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