Supplementary Figures 1-8 from Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figures 1-8. Supplementary Figure 1: TWEAK is internalized and degraded following binding to Fn14-positive cells Supplementary Figure 2: Surface plasmon resonance analysis of TWEAK Supplementary Figure 3: GrB-TWEAK specifically internalizes into Fn14-expressing MDA-MB-231 cells Supplementary Figure 4: Effect of GrB-TWEAK in combination with chemotherapeutic agents on MDA-MB-231 cells Supplementary Figure 5: Caspase-independent PARP cleavage Supplementary Figure 6: Expression of PI-9 in various cancer cell lines Supplementary Figure 7: Change in body weight of mice from the xenograft experiments Supplementary Figure 8: Schematic of GrB-Fc-IT4 fusion protein
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362526514