Supplementary Table 1 and Supplementary Figures 1 through 5 from Mechanisms of Resistance to Cabazitaxel
Year: 2023
Type: supplementary-materials
Abstract: The supplementary data include one table and 5 figures. Table S1 presents cabazitaxel cytotoxic activity in the human breast cancer cell line MCF-7, uterine sarcoma cell line MES-SA, and ovarian cancer cell lines ES-2, MES-OV, and OVCAR-3. Figure S1 presents the molecular structure of cabazitaxel and cytotoxicity curves for three taxanes in MCF-7 cells. Figure S2 shows an immunoblot of drug transporter proteins in parental and drug resistant variants of MCF-7. Figure S3 shown rhodamine123 and BODIPY-paclitaxel accumulation by flow cytometry in parental and resistant variants. Figure S4 shows polymerized versus soluble tubulin in parental vs resistant variants. Figure S5 shows expression of apoptotic regulators.
Authors: George E. Duran, Yan C. Wang, E. Brian Francisco, John C. Rose, Francisco J. Martinez, John Coller, Diana Brassard, Patricia Vrignaud, Branimir I. Sikic
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362526701