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Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Year: 2023

Type: supplementary-materials

Abstract: GI50 calculation of spheroids treated with inhibitors. (A) MDA-MB-468 on day 8 and (B) PC3 spheroids on day 12 treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Between 5 and 15 spheroids were measured per condition, errors bars represent standard deviation and GI50 values were calculated using Graph Prism.

DOI: 10.1158/1535-7163.22508371

Authors: Dylan T. Jones, Alessandro Valli, Syed Haider, Qifeng Zhang, Elizabeth A. Smethurst, Zachary T. Schug, Barrie Peck, Eric O. Aboagye, Susan E. Critchlow, Almut Schulze, Eyal Gottlieb, Michael J.O. Wakelam, Adrian L. Harris

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362527799

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