Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Year: 2023
Type: supplementary-materials
Abstract: Significant differential abundance analysis of lipids as a heat map. A. MDA-MB-468 and B. PC3 spheroids were treated for 4 days with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and kinases PI3K, AKT and mTOR at two different concentrations. All Lipids were compared against DMSO control, normalised to viable cells. Only lipids that were differentially abundant (p<0.05) following treatment by at least one drug (see dots in heat map) are epresented. Side covariates indicate lipid families, and lipids within each family are sorted by name. Paired t-test was used where 3 replicat es were available. Only fold change is reported where 2 samples were available. (p<0.05 and absolute log2FC>1).
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362527983