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Supplementary materials from Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth

Year: 2023

Type: supplementary-materials

Abstract: Table S1. UV calibration line parameters for BMMPI quantification. Figure S1. MMP-2 expression in murine and human breast cancer cell lines and BMMPI structure. Figure S2. Selective MMP-2 inhibition by the BMMPIs ML104 and ML115. Figure S3. Impact of BMMPIs on 4T1 bone metastatic breast cancer growth and osteolysis. Figure S4. ML115 is rapidly cleared from the plasma and accumulates in the bone marrow microenvironment over time. effects.Figure S5. The addition of exogenous TGFβ protects breasts cancer cells from BMMPI

DOI: 10.1158/1535-7163.22509274

Authors: Marilena Tauro, Gemma Shay, Samer S. Sansil, Antonio Laghezza, Paolo Tortorella, Anthony M. Neuger, Hatem Soliman, Conor C. Lynch

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362528128

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