Supplementary Methods, Figures 1 - 10, Tables 1 - 3 from Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 2066K, S1. MiR-103 and miR-107 inhibit DNA damage-induced RAD51 foci formation in cancer cells. S2. MiR-103 and miR-107 promote chemosensitivity in U2OS cells. S3. MiR-103 and miR-107 promote chemosensitivity to cisplatin and a PARP inhibitor in HeLa and PEO1 C4-2 cells. S4. MiR-107 promotes chemosensitivity in H1299, HeLa and PEO1 C4-2 cells. S5. MiR-103 and miR-107 regulate RAD51 and RAD51D. S6. RAD51 is critical for cellular resistance to cisplatin and a PARP inhibitor. S7. RAD51 downregulation is critical for miR-103/107-mediated regulation of HR. S8. RAD51D downregulation is relevant to miR-103/107-mediated chemosensitivity. S9. Inhibition of miR-103 and miR-107 mildly de-represses RAD51D expression. S10. MiR-103 and miR-107 are inversely correlated with RAD51D mRNA expression in several tumor subtypes. Table S1. Summary of library screening to identify microRNAs that regulate IR-induced RAD51 foci formation. Table S2. Correlation between miR-103 or miR-107 and target gene expression in the NCI-60 panel of cancer cell lines. Table S3. Correlation between miR-103 or miR-107 and target gene expression in several tumor subtypes from TCGA.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362528269