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Supplemental Figure 3 from Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Figure 3. Calcipotriol reduces VDR message while paradoxically increasing VDR protein levels. (A) VDR expression in AsPC-1 by qPCR after treatments described in Figure 3E. (B) Western blots for VDR or tubulin (loading control) for AsPC-1 lysates at indicated timepoints after calcipotriol treatment. Arrowhead indicates specific band representing VDR protein. qPCR reported as mean {plus minus} SEM. Representative experiments from 2-3 biologic replicates are shown. **P<0.01.

DOI: 10.1158/1541-7786.22514919

Authors: Michael D. Arensman, Phillip Nguyen, Kathleen M. Kershaw, Anna R. Lay, Claire A. Ostertag-Hill, Mara H. Sherman, Michael Downes, Christopher Liddle, Ronald M. Evans, David W. Dawson

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362529418

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