Supplementary Figures S1 - S11 from Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1. Functional modules among 384 genes selected for the NMF algorithm. Supplementary Figure S2. Co-occurring somatic mutations in KRAS-mutant LUAC subgroups. Supplementary Figure S3. Distribution of bi-allelic deletion/amplification events in the three KRAS-mutant LUAC subsets. Supplementary Figure S4. Alterations in genes involved in G1/S transition in the three KRAS-mutant LUAC subgroups. Supplementary Figure S5. Clonal fractions for somatically mutated genes in the 68 KRAS-mutant LUACs (TCGA). Supplementary Figure S6. Co-mutation plot for the combined PROSPECT/CHITALE validation dataset of chemotherapy -naïve KRAS-mutant LUACs. Supplementary Figure S7. Co-occurring genetic events in PI3K-AKT-MTOR pathway genes in the three KRAS-mutant LUAC subsets. Supplementary Figure S8. LKB1-loss-dependent up-regulation of adaptive branches of the unfolded protein response in KRAS-mutant LUAC cell lines. Supplementary Figure S9. Enumeration of distinct immune cell populations in the KRAS LUAC sub-groups from PROSPECT. Supplementary Figure S10. Analysis of overall survival (OS) in KRAS-mutant LUAC subsets. Supplementary Figure S11. Integrated analyses for a higher pre-determined number of KRAS-mutant LUAC subsets.
Authors: Ferdinandos Skoulidis, Lauren A. Byers, Lixia Diao, Vassiliki A. Papadimitrakopoulou, Pan Tong, Julie Izzo, Carmen Behrens, Humam Kadara, Edwin R. Parra, Jaime Rodriguez Canales, Jianjun Zhang, Uma Giri, Jayanthi Gudikote, Maria A. Cortez, Chao Yang, Youhong Fan, Michael Peyton, Luc Girard, Kevin R. Coombes, Carlo Toniatti, Timothy P. Heffernan, Murim Choi, Garrett M. Frampton, Vincent Miller, John N. Weinstein, Roy S. Herbst, Kwok-Kin Wong, Jianhua Zhang, Padmanee Sharma, Gordon B. Mills, Waun K. Hong, John D. Minna, James P. Allison, Andrew Futreal, Jing Wang, Ignacio I. Wistuba, John V. Heymach
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362531344