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Supplementary Figure S6 from Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S6. Validation of ADAM10 and ADAM17 siRNA knockdown in MDA-MB157 and MDA-MB231, assessed by live-cell immunostaining and confirmed at right by western blot in MDA-MB231 (*p<0.05).

DOI: 10.1158/2159-8290.22531193

Authors: Miles A. Miller, Madeleine J. Oudin, Ryan J. Sullivan, Stephanie J. Wang, Aaron S. Meyer, Hyungsoon Im, Dennie T. Frederick, Jenny Tadros, Linda G. Griffith, Hakho Lee, Ralph Weissleder, Keith T. Flaherty, Frank B. Gertler, Douglas A. Lauffenburger

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362531373

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