Supplementary Figures from Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Year: 2023
Type: supplementary-materials
Abstract: Fig. S1: Characterization of effects of Entospletinib in AML in vitro and in vivo, Fig. S2: Genome-scale lentiviral ORFeome library screen identifies drivers of entospletinib resistance in AML.; Fig. S3: Viability analysis with increasing concentrations of PRT062067; Fig. S4: Characterization of a MV4-11 cell line with acquired resistance to entospletinib; Fig. S5: PTPN11 mutants confer resistance to entospletinib in AML; Fig S6: Combination of a MEK-Inhibitor and a SYK-Inhibitor is synergistic in in vitro AML models; Fig. S7: Combination of a MEK inhibitor and a SYK inhibitor shows no toxicity in healthy mice
Authors: Anjali Cremer, Jana M. Ellegast, Gabriela Alexe, Elizabeth S. Frank, Linda Ross, S. Haihua Chu, Yana Pikman, Amanda Robichaud, Amy Goodale, Björn Häupl, Sebastian Mohr, Arati V. Rao, Alison R. Walker, James S. Blachly, Federica Piccioni, Scott A. Armstrong, John C. Byrd, Thomas Oellerich, Kimberly Stegmaier
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362532139