Supplementary Figure S3 from Targeting CD20+ Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Fig.S3: U-698-M stimulates the expression of activating receptors on mock exPBNK and CAR exPBNK similarly The expanded NK cells were nucleofected with anti-CD20 CAR mRNA (CAR) or without anti-CD20 CAR mRNA (mock). MOCK exPBNK or CAR exPBNK cells were cultured with medium only, or CD20+ U-698-M at a 3:1 ratio overnight. The activating receptors (NKp30, NKp44, CD69, and NKG2D) and inhibitor receptors (CD94 and KIR2DL2/3) as indicated on MOCK exPBNK and CAR exPBNK were examined and compared by flow cytometry analysis.
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362532152