Supplementary Figures 1-8, Table 1 from DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure 1. Gene ontology molecular function and PANTHER pathway enrichment analysis for genes uniquely dyregulated in HMLE/FOXQ1 and HMLE/SNAI1 cells. Supplementary Figure 2. Gene set enrichment analysis (GSEA) based on 2201 genes commonly dyregulated in HMLE/FOXQ1 and HMLE/SNAL1 cells. Supplementary Figure 3. DDR2 expression in breast cancer. Supplementary Figure 4. DDR2 has minimal effect on EMT. Supplementary Figure 5. The effect of DDR2 on cell proliferation, EMT, cell migration, and invasion in HMLE/LacZ control cells. Supplementary Figure 6. The effect of DDR2 on stemness properties in EMT cell models. Supplementary Figure 7. The effect of DDR2 knockdown on cellular metabolism. Supplementary Figure 8. Model-specific metabolites changes in HMLE/FOXQ1 cells (EMT) and BT549 cells (TNBC) within the TCA. Supplementary Table 1. Twenty-three metabolites commonly dysregulated by DDR2 knockdown in HMLE/FOXQ1 and BT549 cells.
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362533006