Supplementary Figures 1-11 from Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer
Year: 2023
Type: supplementary-materials
Abstract: S1. Experimental design S2. Association between the variant allele frequency (VAF) of tumor mutations identified in uterine lavage with stage of the ovarian cancer (A) and preoperative CA-125 level (B) S3. Gene distribution of the largest mutant clones identified in uterine lavage S4. Correlations between Mutation Frequencies (MF) of genes commonly mutated in lavage DNA S5. Comparison of Mutation Frequencies (MF) by patient group. S6. Comparison of Mutation Frequency (MF) for individual genes in uterine lavages from patients with and without cancer S7. Correlations between TP53 coding mutation frequency (MF) and age S8. Distribution of driver and non-driver mutations identified in lavage DNA by gene and patient S9. Mutation spectrum distribution of coding mutations detected in lavage DNA compared to ovarian cancer mutations reported in COSMIC S10. Comparison of Variant Allele Frequency (VAF) of driver mutations in lavage DNA from patients with and without ovarian cancer S11. Comparison of mutation burden (MB) of common ovarian cancer genes in lavage DNA from patients with and without ovarian cancer
Authors: Talayeh S. Ghezelayagh, Brendan F. Kohrn, Jeanne Fredrickson, Enna Manhardt, Marc R. Radke, Ronit Katz, Heidi J. Gray, Renata R. Urban, Kathryn P. Pennington, John B. Liao, Kemi M. Doll, Elise J. Simons, Jennifer K. Burzawa, Barbara A. Goff, Paul Speiser, Elizabeth M. Swisher, Barbara M. Norquist, Rosa Ana Risques
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362533036