Supplementary Figures S1-S13 from The Tumor Immune Profile of Murine Ovarian Cancer Models: An Essential Tool for Ovarian Cancer Immunotherapy Research
Year: 2023
Type: supplementary-materials
Abstract: Figure S1 shows differential gene expression between cancer cell populations of orthotopic ID8-WT and STOSE tumors. Figure S2 shows UMAP plots of M0/M1/M2 gene set enrichment in ID8-WT and STOSE tumors. Figure S3 shows expression of MHC-I and PD-L1 under IFNγ treatment in various ovarian cancer cell lines. Figure S4 shows tumor phenotypes of various murine ovarian cancer models. Figure S5 shows the gating strategy for analysis of flow cytometry data. Figure S6 shows abundance of T cell populations in the TME of syngeneic ovarian cancer models. Figure S7 shows abundance of myeloid-like cell populations in the TME of various syngeneic ovarian cancer models. Figure S8 shows MHC-II expression in immune and stromal compartments of orthotopic tumors from syngeneic ovarian cancer models. Figure S9 shows PD-L1 expression in immune and stromal compartments of orthotopic tumors from syngeneic ovarian cancer models. Figure S10 shows relative immune cell frequencies found in spleens of ovarian tumor-bearing mice. Figure S11 shows MHC-II and PD-L1 expression in the TME and ascites of ovarian tumor-bearing mice. Figure S12 shows the chemokine and cytokine network found in the ascites and plasma of ovarian tumor-bearing mice. Figure S13 shows chemokine and cytokine expression from single-cell RNA-sequencing analysis of ID8 and STOSE tumors.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362533108