Supplementary Figure 2 from Comparing Histone Deacetylase Inhibitor Responses in Genetically Engineered Mouse Lung Cancer Models and a Window of Opportunity Trial in Patients with Lung Cancer
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 1690K, Supplemental Fig. 2: Pharmacodynamic effects of vorinostat in (A) murine ED-1 lung cancer cells and (B) human HOP62 lung cancer cells. Vorinostat dose-dependent effects were investigated by immunoblot analyses for Bcl-2 family members (Bcl-2, Mcl-1, Bax and Bim); DNA damage response proteins (γH2AX and Chk1); the epithelial-mesenchymal transition (EMT) biomarker E-cadherin; and other growth regulatory proteins (c-raf, p-Akt, Akt, p21, and acetyl-α tubulin).
Authors: Tian Ma, Fabrizio Galimberti, Cherie P. Erkmen, Vincent Memoli, Fadzai Chinyengetere, Lorenzo Sempere, Jan H. Beumer, Bean N. Anyang, William Nugent, David Johnstone, Gregory J. Tsongalis, Jonathan M. Kurie, Hua Li, James DiRenzo, Yongli Guo, Sarah J. Freemantle, Konstantin H. Dragnev, Ethan Dmitrovsky
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362534096