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Supplementary Methods, Figures 1 - 7 from Hrk Mediates 2-Methoxyestradiol–Induced Mitochondrial Apoptotic Signaling in Prostate Cancer Cells

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 321K, Figure S1. Induction of BH3-only protein family members by 2-ME in prostate cancer cells. Figure S2. Hrk knockdown prevents 2-ME-mediated cell death in time-dependent manner. Figure S3. Mitochondrial localization of Hrk. Figure S4. No change in total cell number after 2-ME treatment. Figure S5. Bax is not involved in 2-ME-mediated apoptotic cell death. Figure S6. Endogenous Bak interacts with Bcl-xL but not with Bcl-2 in prostate cancer cells. Figure S7. Hrk requires the BH3 domain for pro-apoptotic function.

DOI: 10.1158/1535-7163.22499694

Authors: Inik Chang, Shahana Majid, Sharanjot Saini, Mohd S. Zaman, Soichiro Yamamura, Takeshi Chiyomaru, Varahram Shahryari, Shinichiro Fukuhara, Guoren Deng, Rajvir Dahiya, Yuichiro Tanaka

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362534172

Cites: 1

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Related to: 10