Work

Figure S6 from RAC1b Overexpression Confers Resistance to Chemotherapy Treatment in Colorectal Cancer

Year: 2023

Type: other

Abstract: Figure S6. (A) Five different colorectal cancer cells showing the sensitivity for GYS32661, KRAS and BRAF mutation and Rac1b expression. (B) HCT116-EV and HCT116-Rac1b cells stably expressing the NFÎºÎ' reporter was treated with different dose of GYS32661. The cells were lysed in reporter lysis buffer and NFÎºB reporter activity was measured. The results, presented as the NF-kB-mediated luciferase activity normalized to the protein concentration are the means {plus minus} SEM from three independent experiments. (C) Mice body weight following treatment with GYS32661.

DOI: 10.1158/1535-7163.22510678

Authors: Erik T. Goka, Pallavi Chaturvedi, Dayrelis T. Mesa Lopez, Adriana De La Garza, Marc E. Lippman

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362535486

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