Figure S6 from A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia
Year: 2023
Type: other
Abstract: Combined AZD1775 and olaparib treatment reduces cell viability and enhances apoptosis in a murine AML cell line. A. A murine MLL-ENL, FLT3-ITD+ AML cell line was treated in vitro with DMSO (vehicle control), olaparib (2 uM), and/or AZD1775 (200 nM) for 72 hr. Viable cell counts are normalized to cells receiving no treatment (NT). Results are shown as mean {plus minus} SEM from three independent experiments. *, P < 0.05. **, P < 0.01. ***, P < 0.001. ****, P < 0.0001. B. A murine AML cell line was treated in vitro with DMSO (vehicle control), olaparib (2 uM), and/or AZD1775 (200 nM) for 72 hr then stained with Annexin V-PE. Results are displayed as mean {plus minus} SEM of three independent experiments. **, P < 0.01. ***, P < 0.001. ****, P < 0.0001.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362535494