Supplementary Figure S2 from Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1
Year: 2023
Type: supplementary-materials
Abstract: Treatment with 1 causes modulation of RAS-GTP and phospho ERK levels in cell lines expressing mutant RAS isoforms. NCI-H1299, NCI-H358, HCT 116 and NCI-H1792 cells were treated with either 25 μM or 50 μM 1 over a time course of up to 180 minutes. EGF (50 ng/mL for 5 minutes) was used as a positive control. Two biological repeats of each experiment were independently conducted.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362535892