Supplementary Figures and Legends 1-9, Supplementary Table 1 from Telomere DNA Damage Signaling Regulates Prostate Cancer Tumorigenesis
Year: 2023
Type: supplementary-materials
Abstract: Fig. S1. Telomere DNA damage is significantly increased in human prostate cancer. Fig. S2. Relative expression of TRF2 and p53 mRNAs in prostate glands from 8 week old K14Cre;TRF2+/+;p53+/+, K14Cre;TRF2f/f;p53+/+, and K14Cre;TRF2f/f;p53f/f mice is shown by qRT-PCR. Fig. S3. Increased senescence, decreased proliferation, and increased cell death in K14Cre;TRF2f/f;p53+/+ prostate epithelium. Fig. S4. Quantitation of SAHF+ cells in prostate glands from K14Cre;TRF2+/+;p53+/+, K14Cre;TRF2f/f;p53+/+, and K14Cre;TRF2f/f;p53f/f mice. Fig. S5. Defective secretion in K14Cre;TRF2f/f;p53+/+ prostate glands. Fig. S6. Telomere DNA damage signaling in K14Cre;TRF2f/f;p53+/+ prostate epithelium. Fig. S7. (A) Quantitation of 53BP1+ cells in prostate glands from K14Cre;TRF2+/+;p53+/+, K14Cre;TRF2f/f;p53+/+, and K14Cre;TRF2f/f;p53f/f mice. Fig. S8. Increased proliferation and reduced differentiation of K14Cre;TRF2f/f;TAg prostate tumors. Fig. S9. Decreased proliferation, increased AR+ differentiation, and apoptosis in K14Cre;TRF2f/f;Terc-/-;TAg prostate glands. Supplementary Table 1. Telomere DNA damage and tumor staging
Authors: Jianchun Wu, David L. Crowe
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362536303