Work

SUPPLEMENTARY DATA from TGFβ1 Protects Cells from γ-IR by Enhancing the Activity of the NHEJ Repair Pathway

Year: 2023

Type: supplementary-materials

Abstract: SUPPLEMENTARY DATA. 7 figures, figure legends and supplementary methods Suppl. Fig. 1. TGF-ß1 pretreatment induces G1 arrest. Suppl. Fig. 2. TGF-ß1 pretreatment protects cells from low dose IR-induced apoptosis, regardless of p21. Suppl. Fig. 3. Smad2 and Smad3 are required for TGF-ß1-mediated suppression of low dose IR-induced apoptosis. Suppl. Fig. 4. TGF-ß1-mediated suppression of IR-induced DSBs is not observed immediately after ?-irradiation. Suppl. Fig. 5. TGF-ß1 pretreatment reduces chromosome breakage. Suppl. Fig. 6. Vectors used for in vivo NHEJ assay. Suppl. Fig. 7. TGF-ß1 pretreatment promotes the nuclear retention of NHEJ proteins.

DOI: 10.1158/1541-7786.22514674.v1

Authors: Mi-Ra Kim, Jeeyong Lee, You Sun An, Yeung Bae Jin, In-Chul Park, Eunkyung Chung, Incheol Shin, Mary Helen Barcellos-Hoff, Jae Youn Yi

Language: English

Topic: Effects of Radiation Exposure

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362536726

Cites:

Cited by:

Related to: 10