Supplemental Figure 1 from PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure 1: The signaling impact of IGF1R activation in sensitive vs. resistant cell lines. Lysates from 6 HNSCC cell lines were assessed by reverse phase protein array (RPPA) to determine protein changes following treatment with desIGF1 (NT+IGF), each single EGFR-TKI (Erl = erlotinib, Gef = gefitinib, or Lap = lapatinib), or the combination of EGFR-TKI and desIGF1 (Erl+IGF, Gef+IGF, or Lap+IGF). Representative heat maps depict changes among the 157 epitopes in each of the 6 cell lines assessed by RPPA. Heat map representing changes upon treatment with (A) gefitinib, (B) erlotinib and (C) lapatinib. Asterisks represent significant changes with p<0.05 as compared to untreated.
Language: English
Topic: HER2/EGFR in Cancer Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362536920