Supplementary Figures S1-S8 from EWS-FLI1–regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1. PHGDH is highly expressed in Ewing sarcoma cell lines; Supplementary Figure S2. Measurement of PHGDH protein expression. Immunoblot analysis of PHGDH in the specified cell lines expressing lentiviral control shRNA (shControl) or no shRNA (Parental); Supplementary Figure S3. PHGDH knockdown and ES proliferation in vitro; Supplementary Figure S4. Effect of GNE-618 on ES cellular proliferation; Supplementary Figure S5. Dose-effect Curves for GNE-618 and NCT-503; Supplementary Figure S6. Mouse body weight is unaffected by inhibitor treatments; Supplementary Figure S7. EWS-FLI1 is important for sarcoma cellular proliferation in the absence of serine; Supplementary Figure S8. Mouse body weight is unaffected by serine/glycine deficient diet
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362537067