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Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Fig S9. Differentially methylated regions of IGF pathway genes align with histone methylation sites. The UCSC Genome Browser was used to align the Irs1, Igf1, and Igfbp4 with other epigenetic modifications. The red bars indicate the regions of differential DNA methylation identified in the SureSelectXT Methyl-Seq Assay. Black bars represent sites of histone methylation, the intensity corresponds to the degree of methylation.

DOI: 10.1158/1940-6207.22526088.v1

Authors: Tiffany A. Katz, Serena G. Liao, Vincent J. Palmieri, Robert K. Dearth, Thushangi N. Pathiraja, Zhiguang Huo, Patricia Shaw, Sarah Small, Nancy E. Davidson, David G. Peters, George C. Tseng, Steffi Oesterreich, Adrian V. Lee

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362537771

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