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Supplementary Figure 7 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Fig S7. Igf1r is central to a top signaling network in Ingenuity pathway analysis. Ingenuity pathway analysis (IPA) identified this signaling network to be significantly altered by DNA methylation. The hyper and hypomethylated genes identified to be persistently differentially methylated by the meta-analysis were input into IPA (Supplemental Data 1). Red symbols represent hypermethylation, green symbols represent hypomethylation and intensity depicts methylation difference between nulliparous and parous.

DOI: 10.1158/1940-6207.22526094.v1

Authors: Tiffany A. Katz, Serena G. Liao, Vincent J. Palmieri, Robert K. Dearth, Thushangi N. Pathiraja, Zhiguang Huo, Patricia Shaw, Sarah Small, Nancy E. Davidson, David G. Peters, George C. Tseng, Steffi Oesterreich, Adrian V. Lee

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362537799

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