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Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition

Year: 2023
Type: supplementary-materials
Abstract: Supplemental Fig S8. Hypermethylation of the Igf1r aligns with sites of histone methylation. (A) The UCSC Genome Browser was used to align the Igf1r with other epigenetic modifications. The red bar indicates the region of differential DNA methylation identified in the SureSelectXT Methyl-Seq Assay. Black bars represent sites of histone methylation, the intensity corresponds to the degree of methylation. (B) Igf1r bisulfite sequencing data are depicted. Each animal is numbered and each horizontal line represents DNA from a separate clone from that animal. The percent methylation of each animal is listed under each CpG site. Open circles = unmethylated, and closed circles = methylated. The lower panel represents a combined result from all clones in all animals.
DOI: 10.1158/1940-6207.22526091.v1
Authors: Tiffany A. Katz, Serena G. Liao, Vincent J. Palmieri, Robert K. Dearth, Thushangi N. Pathiraja, Zhiguang Huo, Patricia Shaw, Sarah Small, Nancy E. Davidson, David G. Peters, George C. Tseng, Steffi Oesterreich, Adrian V. Lee
Language: English
Open Access status: gold
OpenAlex ID: W4362537802
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