Supplementary Figures 1-8 from p53 Frameshift Mutations Couple Loss-of-Function with Unique Neomorphic Activities
Year: 2023
Type: supplementary-materials
Abstract: This file contain Supplementary Information that is relevant to the main body of the text. Supplementary Figure S1. Supplementary Figure S2. Half-lives of WT and mutant I332fs*14 p53 in U2OS and HCT116 cells. Supplementary Figure S3. Subcellular localization of p53 FS mutants expressed in U2OS and HCT116 cells. Supplementary Figure S4. Cross-linked species detected in cells grown in the absence or presence of Photo-Met. Supplementary Figure S5. Transcriptional activity of p53 FS mutants in U2OS and HCT116 cells. Supplementary Figure S6. Transactivation potential of N345K* and N345fs*26 mutants in U2OS cells. Supplementary Figure S7. Cell cycle profiles of I332fs*14-expressing HCT116 and U2OS cells. Supplementary Figure S8. Pro-apoptotic activity of I332fs*14 p53.
Authors: David R. Tong, Wen Zhou, Chen Katz, Kausik Regunath, Divya Venkatesh, Chinyere Ihuegbu, James J. Manfredi, Oleg Laptenko, Carol Prives
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362538024