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Supplementary Figure S3 from Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S3. (A) Pre-ranked GSEA in CALRMUT versus CALRWT expressing Ba/F3-MPL cells 24 hours post-IL-3 withdrawal. Stat5 (left) and Stat3 (right) target genes (Baker et al, 2007) are both enriched in CALRMUT compared to CALRWT-expressing Ba/F3-MPL cells (B) Immunoblotting demonstrates differential phosphorylation of STAT5 in CALRMUT-expressing UT-7-MPL cells. (C) Immunoblotting demonstrates differential phosphorylation of Stat5 and Stat3 in Calr-targeted Ba/F3-MPL-Cas9 cells.

DOI: 10.1158/2159-8290.22531506

Authors: Shannon Elf, Nouran S. Abdelfattah, Edwin Chen, Javier Perales-Patón, Emily A. Rosen, Amy Ko, Fabian Peisker, Natalie Florescu, Silvia Giannini, Ofir Wolach, Elizabeth A. Morgan, Zuzana Tothova, Julie-Aurore Losman, Rebekka K. Schneider, Fatima Al-Shahrour, Ann Mullally

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362538536

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